Caenorhabditis elegans for predictive toxicology
نویسندگان
چکیده
منابع مشابه
Caenorhabditis elegans: An Emerging Model in Biomedical and Environmental Toxicology
The nematode Caenorhabditis elegans has emerged as an important animal model in various fields including neurobiology, developmental biology, and genetics. Characteristics of this animal model that have contributed to its success include its genetic manipulability, invariant and fully described developmental program, well-characterized genome, ease of maintenance, short and prolific life cycle,...
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Transparent, free-living nematode worm. Unsegmented body plan with full set of differentiated tissues (neural, endoderm, ectoderm and muscle). Genome size approximately 97 Mb, as five autosomes and one X sex chromosome. Fully sequenced genome, which comprises approximately 20 000 predicted genes. Defined cell lineage. Has made major contribution to studies of development, cell-to-cell signallin...
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Currently, much effort is invested into the development of non-animal testing strategies to identify the potential of compounds However , it is also clear that in vitro systems represent valuable tools to study certain mechanisms and endpoints but do not reach the complexity of organs or organisms (Ghallab, 2013). Recently, Daston et al. (2014) published a concept, how future research on non-an...
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In this review we address to what extent computational techniques can augment our ability to predict toxicity. The first section provides a brief history of empirical observations on toxicity dating back to the dawn of Sumerian civilization. Interestingly, the concept of dose emerged very early on, leading up to the modern emphasis on kinetic properties, which in turn encodes the insight that t...
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ژورنال
عنوان ژورنال: Current Opinion in Toxicology
سال: 2020
ISSN: 2468-2020
DOI: 10.1016/j.cotox.2020.02.004